Offers cooperation

Formulation, development and evaluation of human and veterinary dosage forms.

 

Main target is preparation of dosage forms with poorly soluble and hardly absorbable APIs; and
formulation of dosage forms with controlled release.

 

Innovation and optimization of technological processes: mixing, granulation, pelletization, micro-
particles preparation, compressing and coating of dosage units.

 

Solid dosage forms:
Powders and blends: grinding, micronizing, mixing.
Granulates: dry, wet, fluid bed and thermoplastic granulation.
Tablets: immediate released (uncoated and coated) and controlled released (matrix and coated)
Hard capsules: filling and coating.
Pellets: extrusion/spheronization, rotary agglomeration with layering.
Microparticles: gelation and evaporation techniques
Mucoadhesives: tablets, multilayer films/patches.
Liquisolid systems: SEDDS, SMEDDS.

 

Liquids and semisolids:
Solutions, emulsions, suspensions, ointments, creams, gels, pastes

 

Scale-up and technology transfers.

 

Process validation and IQ, OQ, PQ consultation.

 

Stability studies (performance and evaluation).

 

Preclinical and clinical evaluation (consultation and partnership).

 

Faraday pail: powders charge measurement.

 

Laser diffraction: particle size analysis.

 

Thermal analysis: DSC (evaluation of polymorphism).

 

HPLC: API determination in solid, semisolid, liquid dosage form and evaluation of extracts and food
supplements. Experience with measurement of saccharides and polysaccharides (size-exclusion
chromatography).

 

Evaluation of natural products – measurement of oxidation activity (DPPH, TEAC, peroxynitrite
scavenging activity), determination of total phenolic, flavon a flavanon compounds.

 

Process optimalization – Design Experiment and Multivariate Analysis.

 

Statistic evaluation (experimental – clinical and technological dates) with statistical evaluation: PCA,
PLS, L-PLS, LDA etc. )

 

Registration documentation - cooperation (EU, USA).

 

Technological documentation – preparing and cooperation (BR, TR, SOP).

 

Patents, utility models - preparation.

 

Preparation of samples for clinical evaluation (experience - EU, USA, Canada, India).