Assoc. Prof. Oldřich FARSA, Ph.D.

 

Education and academic qualifications

  • 2010: Assoc. Prof. in Medicinal Chemistry (University of Veterinary and Pharmaceutical Sciences Brno)
  • 2000: PharmDr. and Ph.D. in Bioorganic Chemistry (Charles University in Prague, Faculty of Pharmacy in Hradec Králové)
  • 1995: Mgr. (Master) in Pharmacy (Charles University in Prague, Faculty of Pharmacy in Hradec Králové)

 

Professional experience

  • 1998-: University of Veterinary and Pharmaceutical Sciences in Brno, Faculty of Pharmacy, Department of Chemical Drugs
  • 1995: Institute for State Control of Veterinary Biologicals and Medicaments, Brno

 

Teaching activities

  • Medicinal Chemistry, Chemistry of Pharmaceutical Excipients, Biologic Drugs, Molecular Principals of Drug Design

 

Research activities

  • design and synthesis of novel potential
    •  nootropics and cognitive enhancers mainly based on an omega-lactame ring
    • aminopeptidases inhibitors
    • transdermal permeation enhancers
    • QSAR studies mainly devoted to
      • blood-brain barrier permeation
      • aminopeptidases inhibition

 

Other academic activities, research projects, grants

  • Grants of the Universities Development Fund (Czech Republic)
  • 1457/2010 Laboratory of microwave synthesis of drugs and pharmaceutical excipients
  • 750/2008 Innovation and upgrade of practical courses in Medicinal Chemistry
  • 2079/2007 Implementation of the subject Chemistry of Pharmaceutical Excipients
  • Grants of the Internal Grant Agency of the University of Veterinary and Pharmaceutical Sciences Brno
  • principal investigator or co-investigator in 10 projects (1999-2013)

Non-university activities

  • Member of the Czech Chemical Society (1999 - )
  • Member of the Committee of the Division of Organic, Bioorganic and Medicinal Chemistry of the Czech Chemical Society (2001-2003)
  • Member of the American Chemical Society (2001-2003)
  • European Medicines Agency (EMA)
  • an extramural expert for providing scientific expertise to  EMA nominated by Institute for State Control of Veterinary Biologicals and Medicaments, Brno, Czech Republic

Most significant professional accomplishments

  • synthesis of organic compounds
  • structural analysis and spectral techniques:
  • 1H- and 13C-NMR
  • IR
  • UV-VIS
  • general analytical techniques:
  • HPLC
  • TLC including instrumental performing
  • instrumental colour measurement (CIE L* a* b*)
  • PC skills:
  • MS Office and compatible (OpenOffice...)
  • fundamentals of Unix Systems (Sun Solaris) and communication between Windows and Unix (ftp, X-Win)
  • chemical drawing editors (Isis Draw, ChemSketch, Marvin...)
  • chemical, biomedical and generally scientific data bases (Reaxys, SciFinder, ChemId, Scopus, PubMed, Web of Konwledge...)
  • molecular visualisation and modelling software (HyperChem, Molgen)
  • chromatography software (Clarity)
  • software for spectra acquiring and processing (VNMR, MestreC, Chroma...)
  • language skills: English, Russian, German (pas.)

Major publications

  • Journal articles

◦   Kubínová, Renata, ŠVAJDLENKA, Emil, SCHNEIDEROVÁ, Kristýna, HANÁKOVÁ, Zuzana, Dall’Acqua, Stefano and FARSA, Oldřich. Polyphenols and diterpenoids from Plectranthus forsteri ‘Marginatus’. Biochemical Systematics and Ecology. 2013, 49: 39-42. ISSN 0305-1978, IF2013= 0.931

◦   FARSA, Oldřich. Chromatographic Behaviour Predicts the Ability of Potential Nootropics to Permeate the Blood-Brain Barrier. Sciencia Pharmaceutica. 2013, 81 (1):81-91. ISSN 0036-8709

◦   FARSA, Oldřich, ŠUBERT, Jan and MAREČKOVÁ, Marie. Hydrolysis and transesterification of parabens in an aqueous solution in the presence of glycerol and boric acid. Journal of Excipients and Food Chemicals. 2011, 2 (2):41-49. ISSN 2150-2668

◦   FARSA, Oldřich, DOLEŽAL, Pavel and HRABÁLEK, Alexandr. Esters and amides of hexanoic acid substituted with tertiary amino group in terminal position and their activity as transdermal permeation enhancers. Journal of the Serbian Chemical Society. 2010, 75 (5):595-603. ISSN 0352-5139, IF2010=0.611

◦   Brychtová, Kateřina, Jampílek, Josef, Opatřilová, Radka, Raich, Ivan, Farsa, Oldřich and Csöllei, Jozef. Bioorganic and Medicinal Chemistry. 2010, 18 (1):73-79. ISSN 0968-0896, IF2010 =3.075

◦   Brychtová, Kateřina, Farsa, Oldřich and Csöllei, Jozef.     Copper catalyzed coupling of α-Bromocarboxylate with ω-Lactam. Letters in Organic Chemistry. 2009, 6 (1):25-28.  ISSN 1570-1786,  IF2010=0.915

◦   Farsa, Oldřich, Dočkal, Milan, Kováčiková, Jana and Benešová, Mária. Synthesis of 2-{[2-(2-oxo-1-azacycloalkyl)acetamido]phenoxy}acetic acids and their activity as aminopeptidase M inhibitors. Journal of the Serbian Chemical Society. 2008, 73 (8-9):771-780. ISSN 0968-0896, IF2008 =0.611

◦   Farsa, Oldřich and Šablatura, Michal. An alternative synthesis of calcium dobesilate, a simple venous insufficiency drug, suitable for use in medical or organic chemistry practical courses. Chemistry. 2008, 17 (4):281-285. ISSN 0861-9255.

◦   Šubert, Jan, Farsa, Oldřich and Marečková, Marie. Stability evaluation of methylparaben and propylparaben in their solution Aqua Conservans using HPLC. Scientia Pharmaceutica. 2007, 75 (4):171-177. ISSN 0036-8709.

◦   Šubert, Jan, Farsa, Oldřich and GAJDOŠOVÁ, Zuzana. Properties of colour reference solutions of the European Pharmacopoeia in CIE L*a*b* colour space. Pharmazie. 2006, 61 (12):1047-1048. ISSN 0031-7144, IF2006 =0.606.

◦   Šubert, Jan, Farsa, Oldřich and CIESLAROVÁ, Markéta. Efficiency of stabilization of low level of coloration of Casteliani's paint without fuchsine with disodium edetate. Pharmazie. 2006, 61 (12):1049-1050. ISSN 0031-7144, IF2006 =0.606.

◦   Burian, Marek, Omelka, Ladislav, Farsa, Oldřich and Hrubanová, Silvia. Aminoxyl radicals from N-phenyl-1-(2-oxo-1-azacycloalkyl)methanesulfonamides. Monatshefte für Chemie. 2006, 137 (9):1169-1175. ISSN 0026-9247, IF 2006 =0.920.

◦    Šubert, Jan, Farsa, Oldřich and GAJDOŠOVÁ, Zuzana. Theory and practice of pharmacopoeial control of the quality of drugs and auxiliary substances VI. Stability of comparative colour solutions of the Czech pharmacopoeia 2002. Česká a Slovenská Farmacie. 2006, 55(4):189-191. ISSN 1210-7816.

◦   Šubert, Jan, Farsa, Oldřich and CIESLAROVÁ, Markéta. Stability of aqueous solution of naphtylethylendiamine-dihydrochloride used in control of drugs. Farmaceutický Obzor. 2005, 74 (12):323-326. ISSN 0014-8172.

◦   Šubert, Jan and Farsa, Oldřich. Derivation absorption spectrophotometry in the ultraviolet region as an alternative to HPLC and other instrumental methods of drug analysis. Česká a Slovenská Farmacie. 2003, 52(5):218-223. ISSN 1210-7816.

◦   Pazourková, Martina, Lojek, Antonín, Číž, Milan, Kubala, Lukáš, Beneš, Luděk and Farsa, Oldřich. Antioxidative activity of pyridoindoles and N-(alkoxyphenyl)-2-(2-oxo-1-aza-1-cykloalkyl) acetamides in biological, enzymatic, and chemical systems. Česká a Slovenská Farmacie. 2003, 52(4):171-175. ISSN 1210-7816.

◦   Farsa, Oldřich, Poláchová, Kateřina and Beneš, Luděk. 2-Pyrrolidinone derivatives as potential therapeutic agents of CNS. Psychiatrie. 2001, 5 (SUPPL. 2): 30-32. ISSN 1211-7579.

◦   Hrabálek, Alexandr, Doležal, Pavel, Farsa, Oldřich, Šklubalová, Zdeňka and Kuneš, Jiří. Esters of 6-dimethylaminohexanoic acid as skin penetration enhancers.  Pharmazie. 2000, 55 (10):759-761. ISSN 0031-7144, IF2000=0.471.

◦   Koreneva, Anna Pavlovna, Farsa, Oldřich, Hrabálek, Alexandr and Koldobskii, Grigorii Isakovich. Tetrazoles: XXXIX. Alkylation of 1-substituted tetrazole-5-thiones under conditions of phase-transfer catalysis. Russian Journal of Organic Chemistry. 1999, 35 (12): 1820-1823.  ISSN 0514-7492, IF1999=0.442.

◦   Hrabálek, Alexandr, Doležal, Pavel, Škubalová, Zdeňka, Farsa, Oldřich and Krebs, Aleš. Transdermal penetration enhancers. Chemické Listy. 1999, 93 (2):116-119. ISSN 0009-2770, IF1999 =0.190.

◦   Gol'tsberg, Mikhail Antonovich, Hrabálek, Alexandr, Farsa, Oldřich, Krebs, Aleš, Doležal, Pavel and Koldobskii,  Grigorii Isakovich. Tetrazoles. XXXII. Reactions of 1-R-Tetrazole-5-Thiones and Their Derivatives under Conditions of Phase Transfer Catalysis. Selection of Phase Transfer Catalyst. Russian Journal of Organic Chemistry. 1996, 32 (9):1367-1369.  ISSN 0514-7492, IF1996 =0.193.

  • Book chapters
    • FARSA, Oldřich. Calcium Dobesilate in Prevention and Treatment of Diabetic Retinopathy. In.: Ola Mohammad Shamsul (Ed.): Diabetic Retinopathy. InTech, Rijeka, 2012. ISBN: 978-953-51-0044-7.
    • Patents
      • US 6187938 B1 Hrabálek Alexandr, Doležal Pavel, Farsa Oldřich, Kroutil Aleš, Krebs Aleš and Šklubalová Zdeňka. w-Amino acid derivatives, processes of their preparation and their use. February 13th, 2001.

 

Assoc. Prof. Oldřich FARSA, Ph.D.

 

Education and academic qualifications

·         2010: Assoc. Prof. in Medicinal Chemistry (University of Veterinary and Pharmaceutical Sciences Brno)

·         2000: PharmDr. and Ph.D. in Bioorganic Chemistry (Charles University in Prague, Faculty of Pharmacy in Hradec Králové)

·         1995: Mgr. (Master) in Pharmacy (Charles University in Prague, Faculty of Pharmacy in Hradec Králové)

 

Professional experience

·         1998-: University of Veterinary and Pharmaceutical Sciences in Brno, Faculty of Pharmacy, Department of Chemical Drugs

·         1995: Institute for State Control of Veterinary Biologicals and Medicaments, Brno

 

Teaching activities

·         Medicinal Chemistry, Chemistry of Pharmaceutical Excipients, Biologic Drugs, Molecular Principals of Drug Design

 

Research activities

·         design and synthesis of novel potential

o     nootropics and cognitive enhancers mainly based on an omega-lactame ring

o    aminopeptidases inhibitors

o    transdermal permeation enhancers

·         QSAR studies mainly devoted to

o    blood-brain barrier permeation

o    aminopeptidases inhibition

 

Other academic activities, research projects, grants

·         Grants of the Universities Development Fund (Czech Republic)

o    1457/2010 Laboratory of microwave synthesis of drugs and pharmaceutical excipients

o    750/2008 Innovation and upgrade of practical courses in Medicinal Chemistry

o    2079/2007 Implementation of the subject Chemistry of Pharmaceutical Excipients

·         Grants of the Internal Grant Agency of the University of Veterinary and Pharmaceutical Sciences Brno

o    principal investigator or co-investigator in 10 projects (1999-2013)

Non-university activities

·         Member of the Czech Chemical Society (1999 - )

o    Member of the Committee of the Division of Organic, Bioorganic and Medicinal Chemistry of the Czech Chemical Society (2001-2003)

·         Member of the American Chemical Society (2001-2003)

·         European Medicines Agency (EMA)

o    an extramural expert for providing scientific expertise to  EMA nominated by Institute for State Control of Veterinary Biologicals and Medicaments, Brno, Czech Republic

Most significant professional accomplishments

·         synthesis of organic compounds

·         structural analysis and spectral techniques:

o    1H- and 13C-NMR

o    IR

o    UV-VIS

·         general analytical techniques:

o    HPLC

o    TLC including instrumental performing

·         instrumental colour measurement (CIE L* a* b*)

·         PC skills:

o    MS Office and compatible (OpenOffice...)

o    fundamentals of Unix Systems (Sun Solaris) and communication between Windows and Unix (ftp, X-Win)

o    chemical drawing editors (Isis Draw, ChemSketch, Marvin...)

o    chemical, biomedical and generally scientific data bases (Reaxys, SciFinder, ChemId, Scopus, PubMed, Web of Konwledge...)

o    molecular visualisation and modelling software (HyperChem, Molgen)

o    chromatography software (Clarity)

o    software for spectra acquiring and processing (VNMR, MestreC, Chroma...)

·         language skills: English, Russian, German (pas.)

Major publications

·         Journal articles

   Kubínová, Renata, ŠVAJDLENKA, Emil, SCHNEIDEROVÁ, Kristýna, HANÁKOVÁ, Zuzana, Dall’Acqua, Stefano and FARSA, Oldřich. Polyphenols and diterpenoids from Plectranthus forsteri ‘Marginatus’. Biochemical Systematics and Ecology. 2013, 49: 39-42. ISSN 0305-1978, IF2013= 0.931

   FARSA, Oldřich. Chromatographic Behaviour Predicts the Ability of Potential Nootropics to Permeate the Blood-Brain Barrier. Sciencia Pharmaceutica. 2013, 81 (1):81-91. ISSN 0036-8709

   FARSA, Oldřich, ŠUBERT, Jan and MAREČKOVÁ, Marie. Hydrolysis and transesterification of parabens in an aqueous solution in the presence of glycerol and boric acid. Journal of Excipients and Food Chemicals. 2011, 2 (2):41-49. ISSN 2150-2668

   FARSA, Oldřich, DOLEŽAL, Pavel and HRABÁLEK, Alexandr. Esters and amides of hexanoic acid substituted with tertiary amino group in terminal position and their activity as transdermal permeation enhancers. Journal of the Serbian Chemical Society. 2010, 75 (5):595-603. ISSN 0352-5139, IF2010=0.611

   Brychtová, Kateřina, Jampílek, Josef, Opatřilová, Radka, Raich, Ivan, Farsa, Oldřich and Csöllei, Jozef. Bioorganic and Medicinal Chemistry. 2010, 18 (1):73-79. ISSN 0968-0896, IF2010 =3.075

   Brychtová, Kateřina, Farsa, Oldřich and Csöllei, Jozef.     Copper catalyzed coupling of α-Bromocarboxylate with ω-Lactam. Letters in Organic Chemistry. 2009, 6 (1):25-28.  ISSN 1570-1786,  IF2010=0.915

   Farsa, Oldřich, Dočkal, Milan, Kováčiková, Jana and Benešová, Mária. Synthesis of 2-{[2-(2-oxo-1-azacycloalkyl)acetamido]phenoxy}acetic acids and their activity as aminopeptidase M inhibitors. Journal of the Serbian Chemical Society. 2008, 73 (8-9):771-780. ISSN 0968-0896, IF2008 =0.611

   Farsa, Oldřich and Šablatura, Michal. An alternative synthesis of calcium dobesilate, a simple venous insufficiency drug, suitable for use in medical or organic chemistry practical courses. Chemistry. 2008, 17 (4):281-285. ISSN 0861-9255.

   Šubert, Jan, Farsa, Oldřich and Marečková, Marie. Stability evaluation of methylparaben and propylparaben in their solution Aqua Conservans using HPLC. Scientia Pharmaceutica. 2007, 75 (4):171-177. ISSN 0036-8709.

   Šubert, Jan, Farsa, Oldřich and GAJDOŠOVÁ, Zuzana. Properties of colour reference solutions of the European Pharmacopoeia in CIE L*a*b* colour space. Pharmazie. 2006, 61 (12):1047-1048. ISSN 0031-7144, IF2006 =0.606.

   Šubert, Jan, Farsa, Oldřich and CIESLAROVÁ, Markéta. Efficiency of stabilization of low level of coloration of Casteliani's paint without fuchsine with disodium edetate. Pharmazie. 2006, 61 (12):1049-1050. ISSN 0031-7144, IF2006 =0.606.

   Burian, Marek, Omelka, Ladislav, Farsa, Oldřich and Hrubanová, Silvia. Aminoxyl radicals from N-phenyl-1-(2-oxo-1-azacycloalkyl)methanesulfonamides. Monatshefte für Chemie. 2006, 137 (9):1169-1175. ISSN 0026-9247, IF 2006 =0.920.

    Šubert, Jan, Farsa, Oldřich and GAJDOŠOVÁ, Zuzana. Theory and practice of pharmacopoeial control of the quality of drugs and auxiliary substances VI. Stability of comparative colour solutions of the Czech pharmacopoeia 2002. Česká a Slovenská Farmacie. 2006, 55(4):189-191. ISSN 1210-7816.

   Šubert, Jan, Farsa, Oldřich and CIESLAROVÁ, Markéta. Stability of aqueous solution of naphtylethylendiamine-dihydrochloride used in control of drugs. Farmaceutický Obzor. 2005, 74 (12):323-326. ISSN 0014-8172.

   Šubert, Jan and Farsa, Oldřich. Derivation absorption spectrophotometry in the ultraviolet region as an alternative to HPLC and other instrumental methods of drug analysis. Česká a Slovenská Farmacie. 2003, 52(5):218-223. ISSN 1210-7816.

   Pazourková, Martina, Lojek, Antonín, Číž, Milan, Kubala, Lukáš, Beneš, Luděk and Farsa, Oldřich. Antioxidative activity of pyridoindoles and N-(alkoxyphenyl)-2-(2-oxo-1-aza-1-cykloalkyl) acetamides in biological, enzymatic, and chemical systems. Česká a Slovenská Farmacie. 2003, 52(4):171-175. ISSN 1210-7816.

   Farsa, Oldřich, Poláchová, Kateřina and Beneš, Luděk. 2-Pyrrolidinone derivatives as potential therapeutic agents of CNS. Psychiatrie. 2001, 5 (SUPPL. 2): 30-32. ISSN 1211-7579.

   Hrabálek, Alexandr, Doležal, Pavel, Farsa, Oldřich, Šklubalová, Zdeňka and Kuneš, Jiří. Esters of 6-dimethylaminohexanoic acid as skin penetration enhancers.  Pharmazie. 2000, 55 (10):759-761. ISSN 0031-7144, IF2000=0.471.

   Koreneva, Anna Pavlovna, Farsa, Oldřich, Hrabálek, Alexandr and Koldobskii, Grigorii Isakovich. Tetrazoles: XXXIX. Alkylation of 1-substituted tetrazole-5-thiones under conditions of phase-transfer catalysis. Russian Journal of Organic Chemistry. 1999, 35 (12): 1820-1823.  ISSN 0514-7492, IF1999=0.442.

   Hrabálek, Alexandr, Doležal, Pavel, Škubalová, Zdeňka, Farsa, Oldřich and Krebs, Aleš. Transdermal penetration enhancers. Chemické Listy. 1999, 93 (2):116-119. ISSN 0009-2770, IF1999 =0.190.

   Gol'tsberg, Mikhail Antonovich, Hrabálek, Alexandr, Farsa, Oldřich, Krebs, Aleš, Doležal, Pavel and Koldobskii,  Grigorii Isakovich. Tetrazoles. XXXII. Reactions of 1-R-Tetrazole-5-Thiones and Their Derivatives under Conditions of Phase Transfer Catalysis. Selection of Phase Transfer Catalyst. Russian Journal of Organic Chemistry. 1996, 32 (9):1367-1369.  ISSN 0514-7492, IF1996 =0.193.

·         Book chapters

o    FARSA, Oldřich. Calcium Dobesilate in Prevention and Treatment of Diabetic Retinopathy. In.: Ola Mohammad Shamsul (Ed.): Diabetic Retinopathy. InTech, Rijeka, 2012. ISBN: 978-953-51-0044-7.

·         Patents

o    US 6187938 B1 Hrabálek Alexandr, Doležal Pavel, Farsa Oldřich, Kroutil Aleš, Krebs Aleš and Šklubalová Zdeňka. w-Amino acid derivatives, processes of their preparation and their use. February 13th, 2001.