Department of Chemical Drugs

Department of Chemical Drugs

 

  • Design, synthesis and structure-activity relationships of compounds as potential antimicrobial and anticancer drugs, potential transdermal enhancers, photosynthesis inhibitors
  • Design, synthesis and structure-activity relationships of potential epigenetic drugs, especially focused on histone deacetylase inhibitors (HDACi).
  • Design, synthesis and structure-activity relationships of potential nootropics and cognitive enhancers mainly based on an ω-lactam ring.
  • Design, synthesis and structure-activity relationships of potential aminopeptidase inhibitors
  • Development of new methodologies for organic synthesis.
  • Total synthesis of natural products.
  • Study of physico-chemical properties of potential drugs, in vitro bioavailability and ADME.
  • In vitro studies of transdermal/intestinal permeation of drugs and influence of permeation enhancers and other parameters.
  • Capillary electrophoresis, CZE chiral separations
  • HPLC of carbohydrates
  • Solid-state analytical techniques.