Pavel BOBÁĽ, Ph.D.

 

Education and academic qualifications

  • 1996: Ph.D. – Slovak Technical University, Faculty of Chemical Technology, Slovak Republic (Organic chemistry)
  • 1989: M.Sc. – Slovak Technical University, Faculty of Chemical Technology, Slovak Republic (Organic chemistry)

Professional experience

  • 2009-: Assistant Professor – Department of Chemical Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic.
  • 2004-2009: Lab manager, senior scientist – Ratiochem Ltd., Brno, Czech Republic.
  • 2001-2004: Team leader – R&D Dept., Section of synthesis of pharmaceutical substances (API), Biotika a.s., Slovenska Lupca, Slovak Republic.
  • 1998-2001: Postdoctoral research fellow – Department of Chemistry, University of Nevada, Reno, USA.
  • 1995-1998: Postdoctoral research fellow – Institute of Chemistry, University of Neuchâtel, Switzerland.
  • 1993-1995: Research assistant – Department of Medicinal Chemistry, Faculty of Pharmacy, Comenius University in Bratislava, Slovak Republic.

Teaching activities

  • Master course in pharmacy: lecturer of Organic Chemistry, Medicinal Chemistry. Supervisor of diploma, rigorous theses and supervisor of Ph.D. students in Medicinal Chemistry.
  • Master course in chemistry: lecturer of Bioorganic Chemistry.

Research activities

  • Design, synthesis and structure-activity relationships of heterocyclic compounds as potential antimicrobial and anticancer drugs.
  • Design, synthesis and structure-activity relationships of potential epigenetic drugs, especially focused on histone deacetylase inhibitors (HDACi).
  • Development of new methodologies for organic synthesis.
  • Total synthesis of natural products.

Professional stays abroad

  • 1998-2001: University of Neuchâtel (Switzerland), Institute of Chemistry, group of Professor R. Neier (postdoctoral research fellowship).
  • 1995-1998: University of Nevada, Reno (USA), Department of Chemistry, group of Professor D.A. Lightner (postdoctoral research fellowship).

Other academic activities, research projects, grants

  • 2013: Design and synthesis of novel HDAC inhibitors as potential therapeutics (IGA VFU Brno 108/2013/FaF). Internal Grant Agency of the University of Veterinary and Pharmaceutical Sciences Brno, principal investigator.
  • 2013: Synthesis of novel 4 arylaminoquinolines and determination the spectrum of their biological activity (IGA VFU Brno 91/2013/FaF). Internal Grant Agency of the University of Veterinary and Pharmaceutical Sciences Brno, member of research group.
  • 2013: Introduction of new experiments to the exercises in organic chemistry (FRVŠ 162/2013/G6). University Development Fund of the Ministry of Education of the Czech Republic, member of research group.
  • 2012: Design and preparation of chiral bifunctional thiourea catalyst for asymmetric synthesis of potential ß3-adrenomimetics (IGA VFU Brno 80/2012/FaF). Internal Grant Agency of the University of Veterinary and Pharmaceutical Sciences Brno, member of research group.
  • 2012: Innovation and modernization of practical exercises in organic chemistry (FRVŠ 1131/2012/F3/a). University Development Fund of the Ministry of Education of the Czech Republic, principal investigator.
  • 2011: Chemoenzymatic synthesis of optically pure enantiomers affecting adrenoreceptors and determination of their enantiomeric purity (IGA VFU Brno 63/2011/FaF). Internal Grant Agency of the University of Veterinary and Pharmaceutical Sciences Brno, member of research group.
  • 2011: Microwave synthesis of new substituted quinoline derivatives as potential antimicrobial agents (IGA VFU Brno 49/2011/FaF). Internal Grant Agency of the University of Veterinary and Pharmaceutical Sciences Brno, principal investigator.
  • 2011: Synthesis of novel HDAC inhibitors – modulation of chromatin structure (IGA VFU Brno 51/2011/FaF). Internal Grant Agency of the University of Veterinary and Pharmaceutical Sciences Brno, principal investigator.

Major publications

  • BobAl, Pavel and BOBalOVa, Janette. An Efficient Chemoselective Reduction of Furan Series Unsaturated Dinitriles. Molecules 2013, vol. 18, no. 2, 2212-2221. [ISSN 1420-3049, IF2011 = 2.386].
  • BobAl, Pavel and Sujan, Josef and otevrel, Jan and ImramovskY, Ales and Padelkovska, Zdenka and Jampilek, Josef. Microwave-Assisted Synthesis of New Substituted Anilides of Quinaldic Acid. Molecules 2012, vol. 17, no. 2, 1292-1306. [ISSN 1420-3049, IF2011 = 2.386].
  • GonEc, Tomas and BobAl, Pavel and Sujan, Josef and PeSko, Matus, and Guo, Jiahui and KrALovA, Katarina and Kos, Jiri and Coffey, Aidan and KollAr, Peter and ImramovskY, Ales and Placek, Lukas and JampIlek, Josef. Investigating the Spectrum of Biological Activity of Substituted Quinoline-2-Carboxamides and Their Isosteres. Molecules 2012, vol. 17, no. 1, 613-644. [ISSN 1420-3049, IF2011 = 2.386].
  • DYCKA, Filip and BobAl, Pavel and MAZANEC, Karel and BOBAlOVA, Janette. Rapid and Efficient Protein Enzymatic Digestion: An Experimental Comparison. Electrophoresis  2012, vol. 33, no. 2, 288–295. [ISSN 0173-0835, IF2011 = 3.303].
  • simone, Jean-Mary and Loiseau, Francois and CARCACHE, David and BobAl, Pavel and JEANNERET-GRIS, Julie and NEIER, Reinhard. Malonylation/Decarboxylation of Furan Derivatives as Key Steps for the Preparation of Nonactic Acid. Part II. Monatsh. Chem 2017, vol. 138, no. 2, 141–147 [ISSN 0026-9247, IF2011 = 1.532].
  • simone, Jean-Mary and Loiseau, Francois and CARCACHE, David and BobAl, Pavel and JEANNERET-GRIS, Julie and NEIER, Reinhard. Malonylation/Decarboxylation of Furan Derivatives as Key Steps for the Preparation of Nonactic Acid. Part I. Monatsh. Chem 2017, vol. 138, no. 2, 131–139 [ISSN 0026-9247, IF2011 = 1.532].
  • Loiseau, Francois and simone, Jean-Mary and CARCACHE, David and BobAl, Pavel and NEIER, Reinhard. Radical Couplings as Key Steps for the Preparation of Derivatives of Nonactic Acid. Monatsh. Chem 2017, vol. 138, no. 2, 121–129 [ISSN 0026-9247, IF2011 = 1.532].
  • BOBalOVa, Janette and BobAl, Pavel and MUTAFOVA-YAMBOLIEVA, Violeta N. High-Performance Liquid Chromatographic Technique for Detection of a Fluorescent Analogue of ADP-Ribose in Isolated Blood Vessel Preparations. Anal. Biochem. 2002, vol. 305, no. 2, 269–276. [ISSN 0003-2697, IF2010 = 3.236].
  • BobAl, Pavel and LIGHTNER, David A. An Inexpensive Selective Procedure for Oxidizing α-Methyl to α-Formyl Pyrroles. J. Heterocycl. Chem. 2001, vol. 38, no. 5, 1219–1221. [ISSN 0022-152X, IF2011 = 1.220].
  • BobAl, Pavel and LIGHTNER, David A. An Improved Coupling Procedure for the Barton-Zard Pyrrole Synthesis. J. Heterocycl. Chem. 2001, vol. 38, no. 2, 527–530. [ISSN 0022-152X, IF2011 = 1.220].
  • BobAl, Pavel and LIGHTNER, David A. One-Step Conversion of 9-Methyl to 9-Formyl-dipyrrinones. Synthesis 2000, no. 13, 1835–1838. [ISSN 0039-7881, IF2011 = 2,466].
  • BOBAL, Pavel and NEIER, Reinhard. The Chemical Synthesis of Porphobilinogen. Trends in Organic Chemistry 1997, vol. 6, 125-144. [ISSN: 0972-4362, Trivandrum, India].
  • BOBAL, Pavel and GAZO, Roman and KADA, Rudolf and ILAVSKY, Dusan and PRONAYOVA, Nada and ZALIBERA, Lubomir. Condensation Reactions of 1,2,3,4-Tetrahydro-6-methyl-2,4-dioxo-5-pyrimidinecarbaldehyde. Collect. Czech. Chem. Commun. 1995, vol. 60, no. 4, 605-611. [ISSN: 0010-0765, IF2011 = 1.283].
  • KADA, Rudolf and BRUNCKOVA, Jarmila and BOBAL, Pavel. Reactions of Diethyl 5-Substituted 2-Furoylmalonate with Secondary Amines. Collect. Czech. Chem. Commun. 1994, vol. 59, no. 6, 1400-1407. [ISSN: 0010-0765, IF2011 = 1.283].
  • SPIRKOVA, Katarina and BOBAL, Pavel and DANDAROVA, Miloslava and ALFOLDI, Juraj. Preparation and Properties of Chalcones of the Furan Series. Collect. Czech. Chem. Commun. 1992, vol. 57, no. 10, 2157-2165. [ISSN: 0010-0765, IF2011 = 1.283].