Department of Chemical Drugs Reserch Group

 

Section of drug synthesis

 

Ing. Pavel Bobáľ, CSc. 

e-mail: bobalp(at)vfu.cz 

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  • Development of new methodologies for organic synthesis.
  • Total synthesis of natural products.
  • Design, synthesis and structure-activity relationships of potential epigenetic drugs, especially focused on histone deacetylase inhibitors (HDACi).

 

Prof. RNDr. Jozef Csöllei, CSc.

e-mail: csolleij(at)vfu.cz

tel.: (+420) 54156 2920

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  • Synthesis and structure-activity relationships of compounds affecting the cardiovascular system with focus on β-adrenolytic, antihypertensive and β3-agonistic activities.

 

Doc. PharmDr. Oldřich Farsa, Ph.D.
e-mail: farsao(at)vfu.cz
tel.: (+420) 54156 2926

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  • design and synthesis of novel potential nootropics and cognitive enhancers, aminopeptidases inhibitors, transdermal permeation enhancers
  • QSAR studies mainly devoted to blood-brain barrier permeation, aminopeptidases inhibition

 

PharmDr. Tomáš Goněc, Ph.D.
e-mail: gonect(at)vfu.cz
tel: (+420) 54156 2925

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  • synthesis and structure characterization of novel compounds with antimicrobial, antimycobacterial and herbicidal activity

 

Doc. PharmDr. Josef Jampílek Ph.D.
e-mail: jampilekj(at)vfu.cz
tel: (+420) 54156 2926

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  • Design, synthesis and structure-activity relationships of compounds as potential antimicrobial and antineoplastic drugs.
  • Design, synthesis and structure-activity relationships of potential photosynthesis inhibitors.
  • Design, synthesis and structure-activity relationships of potential transdermal enhancers.
  • Study of physico-chemical properties of potential drugs and drug polymorphism.
  • Study of in vitro bioavailability, ADME, transdermal therapeutic systems, nanoparticles.
  • Solid-state analytical techniques.

 

 

Section of drug analysis

 

Mgr. Marie Brázdová, Ph.D.
email: brazdovam(at)vfu.cz

tel.: (+420) 54156 2923

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  • molecular oncology, tumour supressor proteins, interactions of proteins with nucleic acids
  • DNA structure and relations between structure and function
  • DNA supercoiling, DNA quadruplexes and triplexes and their interactions with proteins

 

PharmDr. Lenka Coufalová Ph.D.
email: dvorakovala(at)vfu.cz

tel.: (+420) 54156 2923

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  • In vitro studies of transdermal/intestinal permeation of drugs and influence of permeation enhancers and other parameters

 

Assoc. Prof. Ing. et PharmDr. Radka OPATŘILOVÁ, Ph.D., MBA

e-mail: opatrilovar(at)vfu.cz

tel.: (+420) 602 117 086

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  • In vitro studies of transdermal/intestinal permeation of drugs and influence of permeation enhancers and other parameters.
  • Research interests include analysis of drugs and potential drugs, study of physical, chemical and physico-chemical properties of drugs and study of in vitro bioavailability and toxicity by instrumental methods.

 

Doc. RNDr. Jiří Pazourek, Ph.D.
e-mail: pazourekj(at)vfu.cz
tel.: (+420) 54156 2927

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  • Capillary electrophoresis of pharmaceuticals
  • CZE chiral separations
  • HPLC of carbohydrates