Assoc. Prof. Ing. et PharmDr. Radka OPATŘILOVÁ, Ph.D., MBA

 

Education and academic qualifications

  • 2012 – 2014  MBA - Master of Business Administration, International Business School Brno and Nottingham Trent University, Nottingham, UK
  • 2011    Associate Professor in Pharmaceutical (Medicinal) Chemistry, University of Veterinary and Pharmaceutical Sciences Brno, Faculty of Pharmacy, CZ
  • 2005 – 2007   Ing. - Master study programme, University of Technology, Faculty of Chemistry of Brno, CZ
  • 2002 – 2003   PharmDr. - Rigorous proceedings, University of Veterinary and Pharmaceutical Sciences Brno, Faculty of Pharmacy, CZ
  • 1997 – 2002   Ph.D. – Postgraduate Course, University of Veterinary and Pharmaceutical Sciences Brno, Faculty of Pharmacy, CZ
  • 1992 – 1997 Mgr. - Master study programme, University of Veterinary and Pharmaceutical Sciences Brno, Faculty of Pharmacy, CZ

 

Professional experience

  • 2014, February – up till now - Vice-Rector for Education, University of Veterinary and Pharmaceutical Sciences Brno, CZ 
  • 2006 - 2014 - Vice-Dean Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, CZ  
  • 2000, February – up till now - Different positions – Lectures, Senior Lecturer, Associate Professor; since 2012 Head of the Department of Chemical Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, CZ

Teaching activities

  • Lecturer in courses: Analysis of Drugs (compulsory) and Selected Methods of Drug Quality Control (optional) in Czech and English Study Programme at the Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, CZ 
  • Supervisor (Diploma Thesis - 35, Advanced Thesis - 21, Dissertation Thesis - 3) /opponent of thessis under and post graduate students.

Research activities

  • In vitro studies of transdermal/intestinal permeation of drugs and influence of permeation enhancers and other parameters.
  • Research interests include analysis of drugs and potential drugs, study of physical, chemical and physico-chemical properties of drugs and study of in vitro bioavailability and toxicity by instrumental methods.

Other academic activities, research projects, grants

 

  • Member of Doctoral Study Boards: Medicinal Chemistry, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, CZ
  • Chief person and Member of organizing team of Conferences Drug Synthesis and Analysis (1997, 2001, 2004, 2008, 2011) Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, CZ
  • Chief Manager of implementation team of EU project “Improving teaching, managerial and specialized skills and qualities of VFU employees”, CZ 1.07/2.2.00/28.0110 (2011-2014).
  • Chief Coordinator of implementation team of EU project “Innovating Pharmacy curriculum according to work market demands.”, CZ.1.07/2.2.00/28.0196 (2012-2014).

 

Selected grants

  • Member of research group of project GAČR P304/11/2246 “Nanotechnology Approaches for Drug Delivery across Blood-Tissue Barriers” (2011-2014).
  • Principal investigator of project GAČR 203/03/D182 “Basic analytical rating, antioxidative and antiradical activity of newly synthesized substances with potential cardiovascular effect“ (2003-2006)
  • Member of research group of project GAČR 305/06/0863 „Determination of the basic pharmacodynamic and pharmacokinetic parameters of newly synthesized ultrashort-acting betalytics“ (2006-2009)
  • Member of research group of project of project IGA VFU 20/2010/FaF “Penetration of drug through biological membranes and influence of penetration enhancers” (2010).
  • Member of research group of project IGA VFU 194/2009/FaF “Monitoring the effects of penetration enhancers on the amount of permeated drug through the biological membrane” (2009).

 

Non-university activities

  • Member of Czech Chamber of Pharmacists (1997-2012)
  • Member ofCzech Pharmaceutical Society of the Czech Medical Association J.E.Purkyně (since 1997)

 

 

Most significant professional accomplishments

  • Accepted two worldwide patent, three Czech patents and number of articles in journals with impact factor.

Major publications

  • Jampílek, J.; Záruba, K.; Oravec, M.; Kuneš, M.; Babula, P.; Ulbrich, P.; Brezaniová, I.; Opatřilová, R.; Tříska, J.; Suchý, P. Preparation of Silica Nanoparticles Loaded with Nootropics and Their In Vivo Permeation through Blood–Brain Barrier. BioMed Res. Int. 2015, 2015, Article ID 812673 (9 pages).

 

  • OPATŘILOVÁ, Radka and ČERNÍKOVÁ, Aneta and COUFALOVÁ, Lenka and DOHNAL, Jiří and JAMPÍLEK, Josef. In vitro permeation of micronized and nanonized alaptide from semi-solid formulations. Sci. World J. 2013, vol. 2013, Article ID 787283, 8 pages. [ISSN 1537-744X, IF2012 = 1.730]
  • POBORILOVA Zuzana and OPATRILOVA, Radka and BABULA, Petr . Toxicity of aluminium oxide nanoparticles demonstrated using a BY-2 plant cell suspension culture model. Environmental and Experimental Botany 2013, vol. 91, 1– 11. [ISSN 0098-8472, IF2012 = 2.578]
  • BREZOVSKÁ, Monika and JAMPÍLEK, Josef and OPATŘILOVÁ, Radka. A Review of HPLC Methods Used for Determining the Presence of Meloxicam. Curr. Pharm. Anal. 2013, vol. 9, no 1, 69-76. [ISSN 1573-4129, IF2012 = 1.333]
  • OPATŘILOVÁ, Radka and JAMPÍLEK, Josef and RAICH, Ivan and KÁČEROVÁ, Sandra and HAVLÍČEK, Jaroslav and PEKÁREK, Tomáš and DOHNAL, Jiří and CSŐLLEI, Jozef. Synthesis, Characterization and Physico-chemical Properties of New 2-(4-Arylpiperazine-1-yl)-1-(3-methylbenzofuran-2-yl)ethanoles as Potential Antihypertensive Agents. Curr. Org. Chem. 2009, vol. 13, no. 10, 965-975. [ISSN 1385-2728, IF2009 = 2.879]
  • BABULA, Petr and ADAM, Vojtech and OPATRILOVA, Radka ZEHNALEK, J.; HAVEL, Ladislav and KIZEK, Rene. Uncommon heavy metals, metalloids and their plant toxicity: a review. Environ. Chem. Lett., 2008, 6 (4): 189-213. [ISSN 1610-3653. IF2008 = 1.366].
  • MANDELOVÁ, Zuzana and OPATŘILOVÁ, Radka and RAICH, Ivan and HAVLÍČEK, Jaroslav and Káčerová, Sandra and PEKÁREK, Tomáš and TKADLECOVÁ, Marcela and DOHNAL, Jiří and CSŐLLEI, Jozef and JAMPÍLEK, Josef. Synthesis, Physico-Chemical Properties and DFT Calculations of New 2-(4-Arylpiperazine-1-yl)-1-(3-ethylbenzofuran-2-yl)ethanols As Potential Antihypertensive Agents. Curr. Org. Chem. 2011, vol. 15, no. 7, 1081-1096. [ISSN 1385-2728, IF2011 = 3.064]
  • Brychtová, Kateřina and Opatřilová, Radka and Raich, Ivan and Kalinowski, Danuta and Dvořáková, Lenka and Plaček, Lukáš and Csőllei, Jozef and Richardson, Des Robert and Jampílek, Josef. Investigating the Activity of 2-Substituted Alkyl-6-(2,5-dioxopyrrolidin-1-yl)hexanoates as Skin Penetration Enhancers. Bioorg. Med. Chem. 2010, 18 (24), 8556-8565. [ISSN 0968-0896, IF2010=2,978].
  • BRYCHTOVÁ, Kateřina and DVOŘÁKOVÁ, Lenka and OPATŘILOVÁ, Radka and RAICH, Ivan and Káčerová, Sandra and Plaček, Lukáš and KALINOWSKI, Danuta and RICHARDSON, Des Robert and JAMPÍLEK, Josef. Investigation of Substituted 6-Aminohexanoates as Skin Penetration Enhancers. Bioorg. Med. Chem. 2012, vol. 20, no. 1, 86-95. [ISSN 0968-0896, IF2012 = 2.903]
  • Brychtová, Kateřina and Dvořáková, Lenka and Opatřilová, Radka and Raich, Ivan and Káčerová, Sandra and Plaček, Lukáš and Kalinowski, Danuta and Richardson, Des Robert and Jampílek, Josef. Investigation of Substituted 6-Aminohexanoates as Skin Penetration Enhancers. Bioorg. Med. Chem. 2012, 20 (1), 86-95. [ISSN 0968-0896, IF2011 = 2,921].
  • Mrózek, Lech and Dvořáková, Lenka and Mandelová, Zuzana and Rárová, Lucie and Řezáčová, Anna and Plaček, Lukáš and Opatřilová, Radka and Dohnal, Jiří and Král, Vladimír and Drašar, Pavel and Jampílek, Josef. Investigation of New Acyloxy Derivatives of Cholic Acid and Their Esters as Drug Absorption Modifiers. Steroids. 2011, 76 (10-11), 1082-1097. [ISSN 0039-128X, IF2011=2.829].
  • MRÓZEK, Lech and COUFALOVÁ, Lenka and RÁROVÁ, Lucie and PLAČEK, Lukáš and OPATŘILOVÁ, Radka and DOHNAL, Jiří and KRÁĽOVÁ, Katarína and PALETA, Oldřich and KRÁL, Vladimír and DRAŠAR, Pavel and JAMPÍLEK, Josef. New Polyfluorothiopropanoyloxy Derivatives of 5β-Cholan-24-oic Acid Designed as Drug Absorption Modifiers. Steroids 2013, vol. 78, no. 9, 832-844. [ISSN 0039-128X, IF2012 = 2.803]
  • Coufalová, Lenka and Mrózek, Lech and Rárová, Lucie and Plaček, Lukáš and Opatřilová, Radka and Kráľová, Katatína and Paleta, Oldřich and Král, Vladimír and Drašar, Pavel and Jampílek, Josef. New Propanoyloxy Derivatives of 5β-Cholan-24-oic Acid as Drug Absorption Modifiers. Steroids. 2013, 78, 435-453 [ISSN 0039-128X, IF2012=2.803].
  • BARTOSOVA, Ladislava and NOVAK, Filip and BEBAROVA, Marketa, and FRYDRYCH, Marek and BRUNCLIK, Vít and OPATRILOVA, Radka and KOLEVSKA, Jana and MOKRY, Petr and KOLLAR, Peter and STRNADOVA, Vera and SUCHY, Pavel. Antiarrhythmic effect of newly synthesized compound 44Bu on model of aconitine-induced arrhythmia - Compared to lidocaine. Eur J Pharmacol. 2007. Vol. 575 (1-3): 127-133; [IF2007= 2.787].

 

Patents

 

  • Jampílek, J.; Opatřilová, R.; Dvořáková, L.; Brychtová, K.; Dohnal,      J. Utilization of Alaptide as Transdermal Penetration Modifier in      Pharmaceutical Compositions for Human and Veterinary Applications      Containing Non-steroidal Anti-Inflammatory and/or Antipyretic-Analgesic      Drugs. CZ 304915 B6, December      10, 2014.
  • Jampílek, J.; Opatřilová, R.; Řezáčová, A.; Oktábec, Z.; Dohnal, J.      Alaptide: Methods of Effecting its Solubility,      Membrane Permeation and Pharmaceutical Compositions for Human and/or      Veterinary Applications. WO/2014/019556 A1, February      06, 2014.
  • Jampílek, J.; Opatřilová, R.; Coufalová, L.; Černíková, A.; Dohnal,      J. Utilization of Alaptide as Transdermal      Penetration Modifier in Pharmaceutical Compositions for Human and      Veterinary Applications Containing Anti-Inflammatory Drugs and/or      Antimicrobial Chemotherapeutics. WO/2013/020527      A1, February 14, 2013.

 

Books and book chapters

 

  • Dohnal, J.; Jampílek, J.; Řezáčová, A.; Plaček, L.; Grünwaldová,      V.; Brusová, H.; Havlíček, J.; Pekárek, T.; Grafnetterová, T.; Opatřilová,      R.; Krumbholcová, L.; Setnička, V.; Urbanová M.; Král, V. Modern Approaches to Pharmaceutical      Analysis (in Czech). Jiří      Dohnal, Josef Jampílek, Vladimír Král, Anna Řezáčová (Eds.). Faculty of      Pharmacy, University of Veterinary and Pharmaceutical Sciences      Brno, Czech Republic, 2010, 500 pp. [ISBN 978-80-7305-085-6]