Department of Chemical Drugs Reserch Group

 

Research interests

 

  • Design, synthesis and structure-activity relationships of heterocyclic compounds as potential antimicrobial and anticancer drugs.
  • Design, synthesis and structure-activity relationships of potential epigenetic drugs, especially focused on histone deacetylase inhibitors (HDACi).
  • Design, synthesis and structure-activity relationships of compounds affecting cardiovascular system with focus on β-adrenolytic, antihypertensive and β3-agonistic activities.
  • Design, synthesis and structure-activity relationships of potential nootropics and cognitive enhancers mainly based on an ω-lactam ring.
  • Design, synthesis and structure-activity relationships of potential aminopeptidase inhibitors
  • QSAR studies mainly devoted to blood-brain barrier permeation and aminopeptidase inhibition
  • Design, synthesis and structure-activity relationships of potential transdermal enhancers.
  • Design, synthesis and structure-activity relationships potential photosynthesis inhibitors.
  • Development of new methodologies for organic synthesis.
  • Total synthesis of natural products.
  • Study of physico-chemical properties of potential drugs, in vitro bioavailability and ADME.
  • In vitro studies of transdermal/intestinal permeation of drugs and influence of permeation enhancers and other parameters.
  • Investigation of potential drugs and excipients using instrumental analytical methods, mainly high-performance liquid chromatography.
  • Capillary electrophoresis of pharmaceuticals, CZE chiral separations
  • HPLC of carbohydrates
  • Solid-state analytical techniques.

 

We can offer

 

  • Development and validation of HPLC and CE methods
  • Chiral drugs analysis
  • Determination of physico-chemical properties (lipophilicity, solubility, pKa, enzymatic stability)
  • Development of non-biological methods of activity determination.
  • Analytical studies of biologically active substance making influence on reactive forms of oxygen and nitrogen and their effect on origin of neuro-degenerative and cardiovascular diseases, diabetes mellitus etc.
  • Qualitative and quantitative screening of APIs in matrices (plants, extracts, blood, plasma etc.)
  • Determination of enhancer/transporter activity of potential transdermal or intestinal enhancers
  • Determination penetration and/or permeation of drugs through biological membrane using Franz cell (skin), PAMPA, Ussing chamber (intestine)
  • Modification of physico-chemical properties of drugs
  • Commercial synthesis