Research and Development

Department of Chemical Drugs

 

  • Design, synthesis and structure-activity relationships of compounds as potential antimicrobial and anticancer drugs, potential transdermal enhancers, photosynthesis inhibitors
  • Design, synthesis and structure-activity relationships of potential epigenetic drugs, especially focused on histone deacetylase inhibitors (HDACi).
  • Design, synthesis and structure-activity relationships of potential nootropics and cognitive enhancers mainly based on an ω-lactam ring.
  • Design, synthesis and structure-activity relationships of potential aminopeptidase inhibitors
  • Development of new methodologies for organic synthesis.
  • Total synthesis of natural products.
  • Study of physico-chemical properties of potential drugs, in vitro bioavailability and ADME.
  • In vitro studies of transdermal/intestinal permeation of drugs and influence of permeation enhancers and other parameters.
  • Capillary electrophoresis, CZE chiral separations
  • HPLC of carbohydrates
  • Solid-state analytical techniques.

 

Department of Human Pharmacology and Toxicology

 

  • Professionals from various disciplines, such as pharmacokinetic evaluation of drugs, experimental pharmacology and toxicology, veterinary medicine, histology and immunohistochemistry.
  • Final stage of testing on animal models, including repeated administering of clinically used antipsychotics.
  • Accredited laboratory for small laboratory animals, laboratory of organ physiology, laboratory of clinical biochemistry, laboratory of histology and histochemistry, laboratory of pharmacogenomics and laboratory for the work on tissue cultures.
  • Accredited for experiments on laboratory animals.
  • Equipped laboratory for the experiments on small laboratory animals, which complies with the requirements of Specific Pathogen-Free conditions.

 

Department of Natural Drugs

 

  • Isolation and identification of natural products
  • Biological activities of secondary metabolites
  • Plant cell cultures
  • Molecular biology, molecular epidemiology, and biotechnology
  • Fluorescence/confocal microscopy techniques

 

Department of Pharmaceutics

 

  • Formulation, development and evaluation of human and veterinary dosage forms: main target is preparation of dosage forms with poorly soluble and hardly absorbable APIs; and formulation of dosage forms with controlled release.
  • Innovation and optimization of technological processes: mixing, granulation, pelletization, microparticles preparation, compressing and coating of dosage units.
  • Solid dosage forms:
  • Powders and blends: grinding, micronizing, mixing.
  • Tablets: immediate released (uncoated and coated) and controlled released (matrix and coated).
  • Hard capsules: filling and coating.
  • Pellets: extrusion/spheronization, rotary agglomeration with layering.
  • Microparticles: gelation and evaporation techniques.
  • Mucoadhesives: tablets, multilayer films/patches.
  • Lipid formulations: liquisolid systems, SEDDS, SMEDDS.
  • Liquids and semisolids: Solutions, emulsions, suspensions, ointments, creams, gels, pastes
  • Scale-up and technology transfers.
  • Process validation and IQ, OQ, PQ consultation.
  • Stability studies (performance and evaluation).
  • Preclinical and clinical evaluation (consultation and partnership).
  • Technological documentation – preparing and cooperation (BR, TR, SOP...).
  • Preparation of samples for clinical evaluation (experience - EU, USA, Canada, India).